Unveiling the Tapestry: The Gene-Environment Interplay in Drug Abuse

21 Oct

Guest Speaker: Dr Yasmin Hurd

In this episode titled “Unveiling the Tapestry: The Gene-Environment interplay in Drug Abuse”, Dr Yasmin Hurd discusses how our genetics and environment influences the development and continuation of drug abuse. Dr. Hurd’s extensive multidisciplinary research background means she offers a unique perspective on how both nature and nurture shape drug abuse.

Dr. Hurd begins by introducing the cannabis plant, giving a brief insight into its chemistry and the importance of Δ9-tetrahydrocannabinol (THC), the main psychoactive element of cannabis. Importantly, Dr. Hurd explains the “gateway hypothesis” and clears up misconstrued beliefs surrounding the hypothesis.

After, Dr. Hurd talks about the recreational and medicinal uses of cannabis, explaining the distinct roles of THC and Cannabidiol (CBD) in these contexts. She highlights how the societal normalisation of cannabis has led to a diminished perception of its potential for misuse, particularly among younger generations, and why this cultural shift requires careful consideration.

As the conversation progresses, Dr. Hurd introduces the role of animal models in drug abuse research, mentioning insights from her own work and how they have informed a better understanding of the acute and chronic effects of drug abuse. Dr. Hurd emphasises the strengths and limitations of translating animal model findings to human substance use disorders, acknowledging the challenges in replicating the complexity of human addiction in animal studies.

A key theme throughout the episode is the importance of considering environmental and societal factors in the study of substance misuse. Dr. Hurd emphasises how the context in which a person is in—community, societal influences, stressors—play a critical role in substance misuse vulnerability, and she critiques the field of neuroscience for not fully integrating these broader contexts into its research.

Listen now on Spotify